AutoimmuneHemolyticAnemias
Autoimmunehemolyticanemiaisdefinedasincreaseddestructionofredcellsthroughautoimmunemechanisms,usuallymediatedbyautoantibodiesagainsterythrocytesurfaceantigens.Duringthepastdecade,importantnewfindingshaveemergedregardingthecause,pathogenesis,diagnosis,andtreatmentofthisgroupofdisorders.Historically,clinicalpracticewasbasedontheoreticalconsiderations,casereports,andexpertopinion,butmorerecently,severalprospectiveandothersystematicclinicalstudieshavebeenconducted.
Thefirstinternationalconsensusondiagnosisandtherapywaspublishedin,andBritishguidelineshavealsobeenreported.Challengesremain,however,includingawiderapplicationofcurrentknowledge,animprovedunderstandingofpathogenesis,developmentofnewtherapies,andmanagementofrefractorycases.
Autoimmunehemolyticanemiaisa